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US Patent 10487105 Trinucleotide MRNA cap analogs

Patent 10487105 was granted and assigned to Arcturus Therapeutics on November, 2019 by the United States Patent and Trademark Office.

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Patent
Patent

Patent attributes

Patent Applicant
Arcturus Therapeutics
Arcturus Therapeutics
Current Assignee
Arcturus Therapeutics
Arcturus Therapeutics
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
10487105
Date of Patent
November 26, 2019
Patent Application Number
15788742
Date Filed
October 19, 2017
Patent Citations Received
‌
US Patent 12103944 Compositions and methods for synthesizing 5′-capped RNAs
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US Patent 12060568 Temperature-based transient delivery of nucleic acids and proteins to cells and tissues
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US Patent 12070509 Nucleic acids and methods of treatment for cystic fibrosis
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US Patent 12083224 Lipid particles for nucleic acid delivery
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US Patent 11578095 Compositions and methods for synthesizing 5'-Capped RNAs
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US Patent 11685906 Compositions and methods for treating ornithine transcarbamylase deficiency
0
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US Patent 11744887 Coronavirus vaccine compositions and methods
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US Patent 11759515 Compositions and methods for inducing immune responses
...
Patent Primary Examiner
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Patrick T. Lewis
Patent abstract

What is described is a trinucleotide cap analog comprising m7G(5′)p3-N1pN2 for increased efficiency of in vitro transcription of m7G(5′)p3-RNA, wherein m7G is N7-methylguanosine or analog, (5′)p3 is a 5′,5′-triphosphate bridge, and N1 or N2 or both ribonucleotide analogs linked to each other by a phosphate, p, and wherein the trinucleotide cap analog increases the efficiency of in vitro transcription.

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