Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Gjalt W. Huisman0
Xiyun Zhang0
David Elgart0
Nicholas J. Agard0
Date of Patent
January 14, 2020
0Patent Application Number
163676400
Date Filed
March 28, 2019
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.
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