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Patent attributes
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Patent Number
Date of Patent
August 23, 2022
Patent Application Number
17148834
Date Filed
January 14, 2021
Patent Citations
...
Patent Primary Examiner
The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity and enhanced acid stability, while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.
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