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Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
May 14, 2019
Patent Application Number
15432429
Date Filed
February 14, 2017
Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.
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