Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
January 26, 2021
Patent Application Number
16436176
Date Filed
June 10, 2019
Patent Citations
Patent Primary Examiner
Patent abstract
The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity and enhanced acid stability, while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.
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