Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Marie-Ange Buyse0
Bjorn Victor0
Bruno Dombrecht0
Juha Punnonen0
Maribel Beaumont0
Robert A. Kastelein0
Carlo Boutton0
David Vlerick0
...
Date of Patent
January 28, 2020
Patent Application Number
15353867
Date Filed
November 17, 2016
Patent Citations Received
...
Patent Primary Examiner
Patent abstract
The present invention provides multispecific molecules, e.g., comprising more than one ISVD or Nanobody, that bind to PD1 and CTLA4. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.
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