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US Patent 10544222 PD1/CTLA4 binders

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US Patent 12006352 Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
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US Patent 11945869 PD-1 single domain antibodies and therapeutic compositions thereof
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Patent abstract

The present invention provides multispecific molecules, e.g., comprising more than one ISVD or Nanobody, that bind to PD1 and CTLA4. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.

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Patent Inventor Names
Bjorn Victor0
Bruno Dombrecht0
Carlo Boutton0
David Vlerick0
Edward Bowman0
Juha Punnonen0
Maribel Beaumont0
Marie-Ange Buyse0
Robert A. Kastelein0
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US Patent 11708404 Immunoglobulin variable domains
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US Patent 11332519 Serum albumin binders
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US Patent 11485778 Immunoglobulin variable domains
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US Patent 11485777 Immunoglobulin variable domains
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US Patent 11319364 Immunoglobulin variable domains
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US Patent 11312765 Immunoglobulin variable domains
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US Patent 11312764 Immunoglobulin variable domains
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US Patent 11332519 Serum albumin binders
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 US Patent 10544222 PD1/CTLA4 binders

Infobox
Is a
Patent
Patent
Patent jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent number
10544222
Date of patent
January 28, 2020
Patent application number
15353867
Date Filed
November 17, 2016
Patent primary examiner
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Agnieszka Boesen

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