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Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
February 11, 2020
Patent Application Number
16328262
Date Filed
May 22, 2018
Patent Citations
Patent Citations Received
Patent Primary Examiner
Patent abstract
A 3D printed hybrid nozzle device combining a microfluidic mixer with a liquid jet injector that addresses the bottleneck of investigating substrate-initiated biological reaction paths employing serial crystallography with XFELs. The hybrid nozzle provides for injecting aqueous protein crystal jets after fast mixing (<5 ms), reaching reaction time points (e.g., about 10 ms to about 150 ms) suitable to resolve enzyme kinetics.
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