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US Patent 10557807 3D printed microfluidic mixers and nozzles for crystallography

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US Patent 11944967 Deterministic ratchet for sub-micrometer bioparticle separation
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Patent abstract

A 3D printed hybrid nozzle device combining a microfluidic mixer with a liquid jet injector that addresses the bottleneck of investigating substrate-initiated biological reaction paths employing serial crystallography with XFELs. The hybrid nozzle provides for injecting aqueous protein crystal jets after fast mixing (<5 ms), reaching reaction time points (e.g., about 10 ms to about 150 ms) suitable to resolve enzyme kinetics.

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US Patent 11624718 Single piece droplet generation and injection device for serial crystallography
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Infobox
Is a
Patent
Patent
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
105578070
Date of Patent
February 11, 2020
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Patent Application Number
163282620
Date Filed
May 22, 2018
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Patent Citations
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US Patent 10166542 Methods, systems and apparatus for microfluidic crystallization based on gradient mixing
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US Patent 10413920 Nozzle apparatus and two-photon laser lithography for fabrication of XFEL sample injectors
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Patent Citations Received
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US Patent 10969350 Metal electrode based 3D printed device for tuning microfluidic droplet generation frequency and synchronizing phase for serial femtosecond crystallography
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US Patent 11318487 Co-flow injection for serial crystallography
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US Patent 11485632 Modular 3-D printed devices for sample delivery and method
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Patent Primary Examiner
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Taeho Jo
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US Patent 11485632 Modular 3-D printed devices for sample delivery and method
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US Patent 11318487 Co-flow injection for serial crystallography
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 US Patent 10557807 3D printed microfluidic mixers and nozzles for crystallography

Infobox
Is a
Patent
Patent
Patent jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent number
10557807
Date of patent
February 11, 2020
Patent application number
16328262
Date Filed
May 22, 2018
Patent citations
‌
US Patent 10166542 Methods, systems and apparatus for microfluidic crystallization based on gradient mixing
‌
US Patent 10413920 Nozzle apparatus and two-photon laser lithography for fabrication of XFEL sample injectors
Patent primary examiner
‌
Taeho Jo

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