Patent 10975369 was granted and assigned to Translate Bio on April, 2021 by the United States Patent and Trademark Office.
The present invention relates, in part, to methods for large-scale purification of mRNA. The method includes, at least, a step of centrifuging an mRNA suspension in a centrifuge comprising a porous substrate at a speed sufficient to remove process contaminants and to precipitate purified mRNA composition onto the porous substrate.