Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Michael S. Rooney0
Nir Hacohen0
Date of Patent
April 13, 2021
Patent Application Number
15537839
Date Filed
December 21, 2015
Patent Citations
Patent Citations Received
Patent Primary Examiner
Patent abstract
In one aspect, provided herein is a method comprising: (a) (i) determining cytolytic activity in a tumor from the subject; and/or (ii) determining genetic alterations associated with cytolytic activity in the tumor; and (b) administering an immunotherapeutic agent to the subject if (i) cytolytic activity is detected in the tumor and/or (ii) a genetic alteration associated with induction of cytolytic activity, tumor resistance to cytolytic activity and/or suppression of cytolytic activity is detected in the tumor.
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