Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Nir Hacohen0
Michael S. Rooney0
Date of Patent
March 26, 2024
0Patent Application Number
171799560
Date Filed
February 19, 2021
0Patent Citations
...
Patent Primary Examiner
CPC Code
Patent abstract
In one aspect, provided herein is a method comprising: (a) (i) determining cytolytic activity in a tumor from the subject; and/or (ii) determining genetic alterations associated with cytolytic activity in the tumor; and (b) administering an immunotherapeutic agent to the subject if (i) cytolytic activity is detected in the tumor and/or (ii) a genetic alteration associated with induction of cytolytic activity, tumor resistance to cytolytic activity and/or suppression of cytolytic activity is detected in the tumor.
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