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US Patent 11001588 Activating pyruvate kinase R and mutants thereof

Patent 11001588 was granted and assigned to FORMA Therapeutics on May, 2021 by the United States Patent and Trademark Office.

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Is a

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Patent attributes

Patent Applicant

FORMA Therapeutics

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Current Assignee

FORMA Therapeutics

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Neal Green1

David Richard1

Gary Gustafson1

Lorna Mitchell1

Anna Ericsson1

David R. Lancia, Jr.1

Date of Patent

May 11, 2021

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Patent Application Number

165754561

Date Filed

September 19, 2019

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Patent Citations

US Patent 10100043 Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation

US Patent 10208052 Compositions for activating pyruvate kinase

US Patent 10266551 Compounds and uses thereof for the modulation of hemoglobin

US Patent 10315991 Compounds and uses thereof for the modulation of hemoglobin

US Patent 10377741 Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation

US Patent 10435393 Compounds and uses thereof for the modulation of hemoglobin

US Patent 10450269 Compounds and uses thereof for the modulation of hemoglobin

US Patent 10472371 Compositions for activating pyruvate kinase

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Patent Primary Examiner

Charanjit Aulakh

1

Patent abstract

The disclosure provides chemical compounds useful as activators of PKR. PKR activating compounds are useful in the treatment of disease and disorders associated with modulation of PKR and/or PKM2, such as pyruvate kinase deficiency (PKD).

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