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US Patent 11001588 Activating pyruvate kinase R and mutants thereof

Patent 11001588 was granted and assigned to FORMA Therapeutics on May, 2021 by the United States Patent and Trademark Office.

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Patent abstract

The disclosure provides chemical compounds useful as activators of PKR. PKR activating compounds are useful in the treatment of disease and disorders associated with modulation of PKR and/or PKM2, such as pyruvate kinase deficiency (PKD).

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Patent Inventor Names
Anna Ericsson0
David R. Lancia, Jr.0
David Richard0
Gary Gustafson0
Lorna Mitchell0
Neal Green0
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Official Website
https://pdfpiw.uspto.gov/.piw?Docid=110015880
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Infobox
Is a
Patent
Patent
0
Patent Applicant
FORMA Therapeutics
FORMA Therapeutics
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Current Assignee
FORMA Therapeutics
FORMA Therapeutics
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
110015880
Date of Patent
May 11, 2021
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Patent Application Number
165754560
Date Filed
September 19, 2019
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Official Website
https://pdfpiw.uspto.gov/.piw?Docid=110015880
Patent Citations
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US Patent 10004725 Methods of treatment
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US Patent 10017491 Compounds and uses thereof for the modulation of hemoglobin
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US Patent 10034879 Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
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US Patent 10077249 Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde
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US Patent 10100040 Compounds and uses thereof for the modulation of hemoglobin
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US Patent 10100043 Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
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US Patent 10208052 Compositions for activating pyruvate kinase
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US Patent 10266551 Compounds and uses thereof for the modulation of hemoglobin
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US Patent 10315991 Compounds and uses thereof for the modulation of hemoglobin
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US Patent 10377741 Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
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US Patent 10450269 Compounds and uses thereof for the modulation of hemoglobin
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US Patent 10435393 Compounds and uses thereof for the modulation of hemoglobin
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US Patent 10472371 Compositions for activating pyruvate kinase
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US Patent 10493035 Tablets comprising 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
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US Patent 10577345 Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde
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US Patent 10675274 Activating pyruvate kinase R
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US Patent 10683285 Modulators of hemoglobin
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US Patent 10695330 Methods of treatment
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Patent Primary Examiner
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Charanjit Aulakh
0
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