Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Rudy Gerardus Elisabeth Coumans0
Marion Blomenrohr0
Miranda Maria Cornelia Van der Lee0
Patrick Gerhard Groothuis0
Gerardus Joseph Andreas Ariaans0
Jan Schouten0
Date of Patent
May 18, 2021
0Patent Application Number
157787590
Date Filed
November 24, 2016
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present disclosure relates to CDR defined antibodies targeting the 5T4 oncofoetal antigen (TPBG, 5T4, Wnt Activated Inhibitory Factor 1, WAIF1) which exhibit a binding affinity for human 5T4 antigen which is in the same order of magnitude as their affinity for cynomolgus monkey 5T4. Antibody-drug conjugates (ADCs), and their use in the treatment of human solid tumours and haematological malignancies are claimed.
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