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US Patent 11022614 Antibodies binding to trimeric TNF alpha epitopes

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Patent abstract

It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

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Patent Inventor Names
Alastair Lawson0
Daniel John Lightwood0
James Philip O'Connell0
John Robert Porter0
Rebecca Jayne Munro0
Tracy Lynn Arakaki0
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US Patent 11674967 Method of identifying potential inhibitors of APO TNFα trimers
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Official Website
https://pdfpiw.uspto.gov/.piw?Docid=110226140
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https://pdfpiw.uspto.gov/.piw?Docid=11022614
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 US Patent 11022614 Antibodies binding to trimeric TNF alpha epitopes

Infobox
Is a
Patent
Patent
Patent jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent number
11022614
Date of patent
June 1, 2021
Patent application number
15736558
Date Filed
October 22, 2015
Patent citations
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US Patent 10428148 Anti-ALK2 antibody
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US Patent 10705094 TNF receptor signaling modulator assay
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US Patent 10775385 Treatment of autoimmune and inflammatory disorders with asymmetric TNF alpha trimers
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US Patent 10883996 Methods of identifying signaling modulators of the trimeric TNFa
Patent primary examiner
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Elly-Gerald Stoica

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