Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Alison Witte0
Josephine M. Cardarelli0
Mohan Srinivasan0
Date of Patent
July 27, 2021
0Patent Application Number
165031960
Date Filed
July 3, 2019
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides isolated human monoclonal antibodies that bind to IFNAR-1 and that are capable of inhibiting the biological activity of Type I interferons. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting Type I interferon-mediated disorders using the antibodies of the invention, including methods for treating autoimmune disorders, transplant rejection or Graft Versus Host Disease using the antibodies of the invention.
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