Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Mira Tohmé0
Ivan Chan0
James Barnaby Trager0
Luxuan Guo Buren0
Alexandra Leida Liana Lazetic0
Chao Guo0
Date of Patent
February 22, 2022
0Patent Application Number
170894490
Date Filed
November 4, 2020
0Patent Citations
Patent Citations Received
Patent Primary Examiner
Patent abstract
Provided for herein in several embodiments are immune cell-based (e.g., natural killer (NK) cell) compositions comprising CD19-directed chimeric antigen receptors. In some, embodiments the anti-CD19 binder portion of the CAR is humanized. In several embodiments, the humanized anti-CD19 CAR expressing cells exhibit enhanced expression of the CAR as well as enhanced cytotoxicity and/or persistence. Several embodiments include methods of using of the anti-CD19 CAR expressing immune cells in immunotherapy.
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