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US Patent 11365231 Interleukin 15 (IL-15) variants

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Is a

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Peter Rhode0

Kai-Ping Han0

Xiaoyun Zhu0

Hing C. Wong0

Date of Patent

June 21, 2022

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Patent Application Number

166549580

Date Filed

October 16, 2019

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Patent Citations

US Patent 10358478 Multimeric IL-15 soluble fusion molecules and methods of making and using same

US Patent 10450359 IL-15 variants and uses thereof

US Patent 10150805 Multimeric IL-15 soluble fusion molecules and methods of making and using same

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US Patent 10537615 IL-15-based molecules and methods of use thereof

US Patent 10865230 Construction and characterization of multimeric IL-15-based molecules with CD3 binding domains

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Patent Citations Received

US Patent 11992516 Compositions comprising IL-15-based molecules and immune checkpoint inhibitor antibodies

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US Patent 11890323 Method of treating cancer with composition comprising IL-15-based molecules and BCG

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US Patent 11925676 Method for treating neoplasia with an anti-CD38 antibody and an IL-15:IL-15R complex

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Patent Primary Examiner

Bridget E Bunner

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The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.

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