US Patent 11491220 Methods of producing bioconjugates of
Patent 11491220 was granted and assigned to Janssen Pharmaceuticals on November, 2022 by the United States Patent and Trademark Office.
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US Patent 11491220 Methods of producing bioconjugates of
Methods of producing bioconjugates of O-antigen polysaccharides covalently linked to a carrier protein using recombinant host cells are provided. The recombinant host cells used in the methods described herein encode a particular oligosaccharyl transferase enzyme depending on the O-antigen polysaccharide bioconjugate to be produced. The oligosaccharyl transferase enzymes can be PglB oligosaccharyl transferase or variants thereof. Also provided are compositions containing the bioconjugates, and methods of using the bioconjugates and compositions described herein to vaccinate a subject against extra-intestinal pathogenic
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