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US Patent 11643446 Progranulin variants

Patent 11643446 was granted and assigned to Denali Therapeutics on May, 2023 by the United States Patent and Trademark Office.

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Patent
Patent
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Patent attributes

Patent Applicant
Denali Therapeutics
Denali Therapeutics
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Current Assignee
Denali Therapeutics
Denali Therapeutics
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
116434460
Patent Inventor Names
Gunasekaran Kannan0
Ray L. Y. Low0
Rachel Prorok0
Ankita Srivastava0
Gerald Maxwell Cherf0
Katrina W. Lexa0
Date of Patent
May 9, 2023
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Patent Application Number
176977710
Date Filed
March 17, 2022
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Patent Citations
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US Patent 10808036 Anti-transferrin receptor antibodies and methods of use
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US Patent 10870837 Fusion proteins comprising enzyme replacement therapy enzymes
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US Patent 11124567 Anti-TREM2 antibodies and methods of use thereof
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Patent Citations Received
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US Patent 11912778 Methods of engineering transferrin receptor binding polypeptides
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US Patent 11866742 Fusion proteins comprising enzyme replacement therapy enzymes
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Patent Primary Examiner
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Gregory S Emch
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CPC Code
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C07K 2319/30
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C07K 14/475
0

Provided herein are progranulin variants and fusion proteins that comprise a progranulin variant and an Fc polypeptide. Methods of using such proteins to treat progranulin-associated disorders (e.g., a neurodegenerative disease, such as frontotemporal dementia (FTD)) are also provided herein.

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