End user presence and absence states are determined at an information handling system by analyzing infrared time of flight sensor presence detection information with configuration settings based upon operating conditions at the information handling system. User presence and absence state accuracy is validated and invalidated to analyze and determine optimal configuration settings for each of plural operating conditions, such as the location of the information handling system, ambient light and the availability of plural infrared time of flight sensors, such as the availability of secondary infrared time of flight sensors integrated in peripheral devices.