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US Patent 11697827 Systems and methods for gene modification

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Patent Applicant

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Current Assignee

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Date of Patent

July 11, 2023

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Patent Application Number

171167910

Date Filed

December 9, 2020

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Patent Citations

US Patent 9650617 CRISPR hybrid DNA/RNA polynucleotides and methods of use

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US Patent 9738908 CRISPR/Cas systems for genomic modification and gene modulation

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US Patent 9855297 Methods for engineering T cells for immunotherapy by using RNA-guided CAS nuclease system

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US Patent 10000772 Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

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US Patent 10106820 Methods and compositions for modifying a targeted locus

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US Patent 10119133 Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing

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US Patent 10308961 Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

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US Patent 10329574 Methods for the identification of variant recognition sites for rare-cutting engineered double-strand-break-inducing agents and compositions and uses thereof

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Patent Primary Examiner

Catherine S Hibbert

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CPC Code

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The present disclosure provides a method for designing a set of guide RNAs for hybridizing a genomic region of interest. The present disclosure further provides methods of editing at least one genomic region of interest with at least one set of guide RNAs.

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