Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Fangting Wu0
Date of Patent
August 22, 2017
0Patent Application Number
142166550
Date Filed
March 17, 2014
0Patent Citations Received
0
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Patent Primary Examiner
Patent abstract
The invention relates to engineered CRISPR/Cas9 systems for genomic modification and regulation of gene expression in mammalian cells. The specification describes the design and validation of polynucleotides encoding the Streptococcus pyogenes (S. pyogenes) Cas9 gene and protein and variants of that protein, where the nucleotide sequence has been optimized for expression in mammalian cells, and also modified by fused sequences that enhance various aspects of the CRISPR/Cas system. The specification also describes systems for RNA-guided genome engineering and gene regulation in mammalian cells, including human cells.
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