Patent 11753458 was granted and assigned to ALPINE IMMUNE SCIENCES, INC. on September, 2023 by the United States Patent and Trademark Office.
Provided herein are variant CTLA-4 polypeptides and immunomodulatory proteins and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of disease applications, including for treatment of autoimmune or inflammatory conditions. Compositions and methods for making and using such proteins are provided.