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US Patent 11760756 Crystalline form of a PD-1/PD-L1 inhibitor

Patent 11760756 was granted and assigned to Incyte on September, 2023 by the United States Patent and Trademark Office.

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Contents

Is a
Patent
Patent

Patent attributes

Patent Applicant
Incyte
Incyte
Current Assignee
Incyte
Incyte
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
11760756
Patent Inventor Names
Yongzhong Wu
Yongchun Pan
Mei Li
Jiacheng Zhou
Zhongjiang Jia
Pingli Liu
Shili Chen
Date of Patent
September 19, 2023
Patent Application Number
17520264
Date Filed
November 5, 2021
Patent Citations
‌
US Patent 7851489 Pyridinone compounds
‌
US Patent 7943743 Human monoclonal antibodies to programmed death ligand 1 (PD-L1)
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US Patent 8008449 Human monoclonal antibodies to programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
‌
US Patent 7320989 Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists
‌
US Patent 7417065 Immunosuppressant compounds and compositions
‌
US Patent 7488802 Antibodies against PD-1
‌
US Patent 7491245 Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
‌
US Patent 7691870 Benzimidazole carboxamides as raf kinase inhibitors
...
Patent Citations Received
‌
US Patent 12084443 Process of preparing a PD-1/PD-L1 inhibitor
0
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US Patent 11866435 Heterocyclic compounds as immunomodulators
0
Patent Primary Examiner
‌
Niloofar Rahmani
CPC Code
‌
C07D 471/04
Patent abstract

The present invention relates to crystalline forms of the PD-1/PD-L1 inhibitor (R)-1-((7-cyano-2-(3′-(3-(((R)-3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-ylamino)-2,2′-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid, including methods of preparation thereof, and related synthetic intermediates, where the compound is useful in the treatment of various diseases including infectious diseases and cancer.

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