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US Patent 11761951 Methods of selecting therapeutic molecules

Patent 11761951 was granted and assigned to Bristol-Myers Squibb on September, 2023 by the United States Patent and Trademark Office.

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Is a

Patent attributes

Current Assignee

Bristol-Myers Squibb

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

Patent Inventor Names

Richard E. Olson

Marianne Lerbech Jensen

Angela M. Cacace

Peter Hagedorn

Jeffrey M. Brown

Dong LI

Niels Fisker Nielsen

Stephen E. Mercer

...

Date of Patent

September 19, 2023

Patent Application Number

15548390

Date Filed

February 4, 2016

Patent Citations

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US Patent 10799523 Tau antisense oligomers and uses thereof

US Patent 7399845 6-modified bicyclic nucleic acid analogs

US Patent 7919472 Enhanced antisense oligonucleotides

US Patent 8580756 Short oligomer antagonist compounds for the modulation of target mRNA

Patent Primary Examiner

Kimberly Ballard

CPC Code

Patent abstract

The present disclosure provides methods of using a calcium oscillation assay and/or a sequence score calculation to identify a molecule that is safe for administration. The disclosure also includes a method of selecting or identifying a molecule having tolerable in vivo neurotoxicity using a calcium oscillation assay, a sequence score method, an in vivo tolerability assay, or any combination thereof.

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