Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Andrew M. Siwkowski0
Brett P. Monia0
Sanjay Bhanot0
Date of Patent
April 5, 2011
0Patent Application Number
112312430
Date Filed
September 19, 2005
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Described herein are gap-widened antisense oligonucleotides having improved therapeutic index as compared to 5-10-5 MOE gapmer antisense oligonucleotides of the same sequence. Also described are methods of reducing a target RNA in an animal using the gap-widened antisense oligonucleotides of the present invention. Further, are methods for selecting a gap-widened antisense oligonucleotides.
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