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US Patent 7919472 Enhanced antisense oligonucleotides

Patent 7919472 was granted and assigned to Ionis Pharmaceuticals on April, 2011 by the United States Patent and Trademark Office.

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Is a

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Patent attributes

Current Assignee

Ionis Pharmaceuticals

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Andrew M. Siwkowski0

Brett P. Monia0

Sanjay Bhanot0

Date of Patent

April 5, 2011

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Patent Application Number

112312430

Date Filed

September 19, 2005

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Patent Citations Received

US Patent 11879125 GalNAc compositions for improving siRNA bioavailability

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US Patent 11761951 Methods of selecting therapeutic molecules

Patent Primary Examiner

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Patent abstract

Described herein are gap-widened antisense oligonucleotides having improved therapeutic index as compared to 5-10-5 MOE gapmer antisense oligonucleotides of the same sequence. Also described are methods of reducing a target RNA in an animal using the gap-widened antisense oligonucleotides of the present invention. Further, are methods for selecting a gap-widened antisense oligonucleotides.

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