A mobile packaging system and method to increase the efficiency of the picking and packaging process of items to be shipped from a warehouse or similar facility. A mobile packaging cart that is moved to a location adjacent to the storage location of the item to be packaged. The item to be packaged is retrieved from the storage location and identified, packaged, and the package is labeled at the location by the subsystems of the mobile packaging cart. The completed packages are stored on the mobile packaging cart until being unloaded for shipping from, or further processing within, the facility.