Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Justin Skoble
Alexandre Charles Michel Iannello
Laura Hix Glickman
Christopher D. Thanos
Date of Patent
October 10, 2023
Patent Application Number
16520155
Date Filed
July 23, 2019
Patent Citations
...
Patent Primary Examiner
CPC Code
Patent abstract
Provided are delivery immunostimulatory bacteria that have enhanced colonization of tumors, the tumor microenvironment and/or tumor-resident immune cells, and enhanced anti-tumor activity. The immunostimulatory bacteria are modified by deletion of genes encoding the flagella or modification of the genes so that functional flagella are not produced, and/or are modified by deletion of pagP or modification of pagP to produce inactive PagP product. As a result, the immunostimulatory bacteria are flagellin
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