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US Patent 11786578 Modified relaxin polypeptides and their uses

Patent 11786578 was granted and assigned to Ambrx on October, 2023 by the United States Patent and Trademark Office.

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 US Patent 11786578 Modified relaxin polypeptides and their uses

Article

Patent abstract

Modified relaxin polypeptides and their uses thereof are provided. Exemplary embodiments provide relaxin polypeptides which include one or more amino acid substitutions with natural or non-naturally encoded amino acids, and/or linkage to a water-soluble polymer, such as polyethylene glycol. Additionally, use of said relaxin polypeptides for treatment of disease, such as heart failure, is also provided.

Infobox
Is a
Patent
Patent
Patent Applicant
Ambrx
Ambrx
Current Assignee
Ambrx
Ambrx
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
11786578
Patent Inventor Names
Amha Hewet
Jason Pinkstaff
Kristine De Dios
Lorraine Sullivan
Nick Knudsen
Vadim Kraynov
Date of Patent
October 17, 2023
Patent Application Number
17685658
Date Filed
March 3, 2022
Patent Citations
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US Patent 7230068 Polymer derivatives
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US Patent 7332571 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
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US Patent 7385028 Derivatization of non-natural amino acids and polypeptides
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US Patent 7632823 Compositions of tRNA and uses thereof
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US Patent 7632924 Antigen-binding polypeptides and their uses
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US Patent 7638299 Biosynthetic polypeptides utilizing non-naturally encoded amino acids
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US Patent 7638491 Therapies using non-natural amino acids and polypeptides
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US Patent 7696312 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
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US Patent 7736872 Compositions of aminoacyl-TRNA synthetase and uses thereof
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US Patent 7737226 Acetylene group-containing poly(alkylene oxide, oxyethylated polyol or olefinic alcohol)
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US Patent 7816320 Formulations of human growth hormone comprising a non-naturally encoded amino acid at position 35
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US Patent 7820766 Branched acetylene-containing poly(alkylene oxides, oxyethylated polyols or olefinic alcohols)
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US Patent 7829310 Compositions of aminoacyl-tRNA synthetase and uses thereof
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US Patent 7838265 Compositions of aminoacyl-tRNA synthetase and uses thereof
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US Patent 7846689 Compositions of aminoacyl-tRNA synthetase and uses thereof
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US Patent 7858344 Compositions of aminoacyl-tRNA synthetase and uses thereof
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US Patent 7883866 Compositions of aminoacyl-tRNA synthetase and uses thereof
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US Patent 7888533 Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides
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US Patent 7919591 Modified human plasma polypeptide or Fc scaffolds and their uses
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US Patent 7928163 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
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US Patent 7939496 Modified human growth horomone polypeptides and their uses
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US Patent 7947473 Methods for expression and purification of pegylated recombinant human growth hormone containing a non-naturally encoded keto amino acid
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US Patent 7959926 Methods for expression and purification of recombinant human growth hormone mutants
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US Patent 8008428 Azide- or acetylene-terminated poly(alkylene oxide, oxyethylated polyol or olefinic Alcohol)
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US Patent 8008456 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
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US Patent 8012931 Modified FGF-21 polypeptides and their uses
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US Patent 8022186 Modified human plasma polypeptide or Fc scaffolds and their uses
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US Patent 8048988 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
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US Patent 8053560 Modified human plasma polypeptide or Fc scaffolds and their uses
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US Patent 8071809 Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides
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US Patent 8080391 Process of producing non-naturally encoded amino acid containing high conjugated to a water soluble polymer
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US Patent 8093356 Pegylated human interferon polypeptides
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US Patent 8097702 Modified human interferon polypeptides with at least one non-naturally encoded amino acid and their uses
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US Patent 8114630 Modified interferon beta polypeptides and their uses
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US Patent 8119603 Modified human interferon polypeptides and their uses
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US Patent 8143216 Modified human growth hormone
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US Patent 8153758 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
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US Patent 8163695 Formulations of human growth hormone comprising a non-naturally encoded amino acid
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US Patent 8178108 Methods for expression and purification of recombinant human growth hormone
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US Patent 8178494 Modified human growth hormone formulations with an increased serum half-life
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US Patent 8232371 Modified human interferon polypeptides and their uses
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US Patent 8263740 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
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US Patent 8278418 Modified animal erythropoietin polypeptides and their uses
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US Patent 8329869 Modified interferon beta polypeptides and their uses
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US Patent 8367612 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
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US Patent 8383365 Methods of making FGF-21 mutants comprising non-naturally encoded phenylalanine derivatives
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US Patent 8399614 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
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US Patent 8420792 Suppressor tRNA transcription in vertebrate cells
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US Patent 8476411 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
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US Patent 8557781 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
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US Patent 8569233 Modified animal erythropoietin polypeptides and their uses
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US Patent 8618257 Modified human plasma polypeptide or Fc scaffolds and their uses
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US Patent 8735539 Relaxin polypeptides comprising non-naturally encoded amino acids
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US Patent 8778880 Human growth hormone modified at position 35
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US Patent 8791231 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
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US Patent 8809511 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
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US Patent 9452222 Nucleic acids encoding modified relaxin polypeptides
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US Patent 9567386 Therapeutic uses of modified relaxin polypeptides
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US Patent 9962450 Method of treating heart failure with modified relaxin polypeptides
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US Patent 10253083 Therapeutic uses of modified relaxin polypeptides
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US Patent 10266578 Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
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US Patent 10702588 Modified relaxin polypeptides comprising a non-naturally encoded amino acid in the A chain
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US Patent 10751391 Methods of treatment using modified relaxin polypeptides comprising a non-naturally encoded amino acid
Patent Primary Examiner
‌
Christine J. Saoud

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