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US Patent 11786607 RNA formulations

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 US Patent 11786607 RNA formulations

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Patent abstract

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins.

Infobox
Is a
Patent
Patent
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
11786607
Patent Inventor Names
Charles Bowerman
Joseph Schariter
Michael H. Smith
Stephen Hoge
Yan Xia
Date of Patent
October 17, 2023
Patent Application Number
16623069
Date Filed
June 15, 2018
Patent Citations
‌
US Patent 7094423 Methods for preparation of lipid-encapsulated therapeutic agents
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US Patent 7371404 Amphoteric liposomes and their use
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US Patent 8058069 Lipid formulations for nucleic acid delivery
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US Patent 8158601 Lipid formulation
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US Patent 8420123 Drug loaded polymeric nanoparticles and methods of making and using same
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US Patent 8460696 Polyamine derivatives
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US Patent 8466122 Trialkyl cationic lipids and methods of use thereof
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US Patent 8563041 Therapeutic particles suitable for parenteral administration and methods of making and using same
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US Patent 8569256 Cationic lipids and methods for the delivery of therapeutic agents
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US Patent 8603499 Cancer cell targeting using nanoparticles
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US Patent 8603500 Cancer cell targeting using nanoparticles
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US Patent 8603501 Cancer cell targeting using nanoparticles
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US Patent 8603534 Drug loaded polymeric nanoparticles and methods of making and using same
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US Patent 8603535 Stable formulations for lyophilizing therapeutic particles
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US Patent 8613951 Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same
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US Patent 8628801 Pegylated nanoparticles
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US Patent 8642076 Lipid containing formulations
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US Patent 8663599 Pharmaceutical composition of nanoparticles
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US Patent 8663700 Drug loaded polymeric nanoparticles and methods of making and using same
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US Patent 8691750 Lipids and compositions for intracellular delivery of biologically active compounds
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US Patent 8691966 RNA containing modified nucleosides and methods of use thereof
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US Patent 8697098 Polymer conjugated protein micelles
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US Patent 8709483 System for targeted delivery of therapeutic agents
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US Patent 8710200 Engineered nucleic acids encoding a modified erythropoietin and their expression
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US Patent 8734853 HDL particles for delivery of nucleic acids
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US Patent 8754062 DLIN-KC2-DMA lipid nanoparticle delivery of modified polynucleotides
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US Patent 8822663 Engineered nucleic acids and methods of use thereof
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US Patent 8980864 Compositions and methods of altering cholesterol levels
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US Patent 8999380 Modified polynucleotides for the production of biologics and proteins associated with human disease
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US Patent 9221891 In vivo production of proteins
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US Patent 9283287 Modified polynucleotides for the production of nuclear proteins
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US Patent 9303079 Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
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US Patent 9364433 Parenteral formulations of lipophilic pharmaceutical agents and methods for preparing and using the same
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US Patent 9464124 Engineered nucleic acids and methods of use thereof
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US Patent 9512456 Enzymes and polymerases for the synthesis of RNA
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US Patent 9533047 Delivery and formulation of engineered nucleic acids
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US Patent 9572896 In vivo production of proteins
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US Patent 9597380 Terminally modified RNA
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US Patent 9675668 Modified polynucleotides encoding hepatitis A virus cellular receptor 2
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US Patent 9693958 Methods and devices for preparation of lipid nanoparticles
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US Patent 9803199 Cationic lipid
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US Patent 9868691 Compounds and compositions for intracellular delivery of therapeutic agents
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US Patent 9872900 Nucleic acid vaccines
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US Patent 10023626 Polynucleotides encoding immune modulating polypeptides
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US Patent 10064934 Combination PIV3/hMPV RNA vaccines
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US Patent 10064935 Human cytomegalovirus RNA vaccines
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US Patent 10124055 Zika virus RNA vaccines
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US Patent 10207010 Compositions and methods for delivery of agents
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US Patent 10232055 RNA containing modified nucleosides and methods of use thereof
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US Patent 10286086 Alternative nucleic acid molecules and uses thereof
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US Patent 10273269 High potency immunogenic zika virus compositions
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US Patent 10323076 Polynucleotides encoding low density lipoprotein receptor
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US Patent 10385088 Polynucleotide molecules and uses thereof
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US Patent 10449244 Zika RNA vaccines
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US Patent 10465190 In vitro transcription methods and constructs
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US Patent 10493143 Sexually transmitted disease vaccines
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US Patent 10526629 RNA polymerase variants
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US Patent 10653712 High purity RNA compositions and methods for preparation thereof
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US Patent 10653767 Zika virus MRNA vaccines
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US Patent 10695419 Human cytomegalovirus vaccine
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US Patent 10857105 Compounds and compositions for intracellular delivery of therapeutic agents
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US Patent 10925958 Influenza vaccine
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US Patent 11027025 Compositions comprising synthetic polynucleotides encoding CRISPR related proteins and synthetic sgRNAs and methods of use
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US Patent 11045540 Varicella zoster virus (VZV) vaccine
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US Patent 11351242 HMPV/hPIV3 mRNA vaccine composition
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US Patent 11384352 RNA affinity purification
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US Patent 11406703 Human cytomegalovirus vaccine
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US Patent 11464848 Respiratory syncytial virus vaccine
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US Patent 11485960 RNA polymerase variants for co-transcriptional capping
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US Patent 11497807 Zoonotic disease RNA vaccines
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US Patent 11564893 Methods for preparing particles and related compositions
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US Patent 11576961 Broad spectrum influenza virus vaccine
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US Patent 11643441 Nucleic acid vaccines for varicella zoster virus (VZV)
Patent Primary Examiner
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Michael P Cohen
CPC Code
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A61K 47/6931
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A61K 31/7105

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