A control system in a delivery system performs a method to deliver a payload by an unmanned aerial vehicle, UAV, without requiring presence of the recipient even if the payload comprises sensitive or vulnerable goods. The method comprises obtaining a designated location for delivery of the payload, obtaining at least one payload vulnerability index for the payload, and obtaining a pick-up time indicative of a time point when the payload is expected to be retrieved by the recipient. The method further comprises selecting a final delivery area at or near the designated location as a function of the at least one payload vulnerability index and the pick-up time, and operating the UAV to deliver the payload to the final delivery area.