Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Yun Cheol Kim
Chao Bai Huang
David Rabuka
Date of Patent
October 17, 2023
Patent Application Number
17532797
Date Filed
November 22, 2021
Patent Citations
...
Patent Primary Examiner
Patent abstract
Antibodies that include a sulfatase motif-containing tag in a constant region of an immunoglobulin (Ig) light chain polypeptide are disclosed. The sulfatase motif can be converted by a formylglycine-generating enzyme (FGE) to produce a formylglycine (fGly)-modified Ig light chain polypeptide. An fGly-modified Ig light chain polypeptide of the antibody can be covalently and site-specifically bound to a moiety of interest to provide an antibody conjugate. The disclosure also encompasses methods of production of such tagged Ig light chain polypeptides, fGly-modified Ig light chain polypeptides, and antibody conjugates, as well as methods of use of same.
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