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US Patent 7087600 Peptidyl prodrugs and linkers and stabilizers useful therefor

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Is a

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Oliver L. Saunders0

Danny P. C. McGee0

Guoxian Wu0

Howard P. Ng0

Irina Astafieva0

Jimmie Moore0

Sanjeev Gangwar0

Zhihong Li0

Date of Patent

August 8, 2006

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Patent Application Number

101612340

Date Filed

May 31, 2002

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Patent Citations Received

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US Patent 12129297 Antibodies against TIM3 and uses thereof

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US Patent 11788066 Antibody conjugates and methods of making and using the same

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Patent Primary Examiner

Bruce R. Campell

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Patent abstract

The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.

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