Multi-mode non-return-to-zero (NRZ) and orthogonal differential vector signaling (ODVS) clock and data recovery circuits having configurable sub-channel multi-input comparator (MIC) circuits for forming a composite phase-error signal from a plurality of data-driven phase-error signals generated using phase detectors in a plurality of receivers configured as ODVS sub-channel MICs generating orthogonal sub-channel outputs in a first mode and a separate first and second data driven phase-error signal from two receivers of a plurality of receivers configured as NRZ receivers in a second mode.