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US Patent 11858981 Humanization of rabbit antibodies using a universal antibody framework

Patent 11858981 was granted and assigned to Novartis on January, 2024 by the United States Patent and Trademark Office.

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Patent Applicant

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Current Assignee

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

David Urech0

Leonardo Borras0

Date of Patent

January 2, 2024

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Patent Application Number

158449840

Date Filed

December 18, 2017

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Patent Citations

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US Patent 9873737 Stable and soluble antibodies inhibiting VEGF

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Patent abstract

The present invention relates to an universal antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a universal antibody acceptor framework. Antibodies generated by the methods of the invention are useful in a variety of diagnostic and therapeutic applications.

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