Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
August 23, 2016
Patent Application Number
14134779
Date Filed
December 19, 2013
Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF-mediated disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
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