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US Patent 11865167 Treatment of cancer using humanized anti-EGFRvIII chimeric antigen receptor

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Carl H. June0

Jennifer Brogdon0

Marcela Maus0

Laura Alexandra Johnson0

John Scholler0

Andreas Loew0

Hideho Okada0

Date of Patent

January 9, 2024

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Patent Application Number

163824020

Date Filed

April 12, 2019

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Patent Citations

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US Patent 9394368 Treatment of cancer using humanized anti-EGFRvIII chimeric antigen receptor

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US Patent 9573988 Effective targeting of primary human leukemia using anti-CD123 chimeric antigen receptor engineered T cells

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Patent Primary Examiner

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Patent abstract

The invention provides compositions and methods for treating diseases associated with expression of EGFRvIII. The invention also relates to chimeric antigen receptor (CAR) specific to EGFRvIII, vectors encoding the same, and recombinant T cells comprising the anti-EGFRvIII CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an anti-EGFRvIII binding domain.

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