US Patent 11878998 Prefusion RSV F proteins and their use
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US Patent 11878998 Prefusion RSV F proteins and their use
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Patent abstract
Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.
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Patent Inventor Names
Aliaksandr Druz0
Baoshan Zhang0
Barney Graham0
Cinque Soto0
Emily Rundlet0
Guillaume Stewart-Jones0
Ivelin Stefanov Georgiev0
John Mascola0
Joseph Van Galen0
Li Ou0
Mallika Sastry0
Man Chen0
Marie Pancera0
Michael Gordon Joyce0
Paul Thomas0
Peter Kwong0
Ulrich Baxa0
Wing-Pui Kong0
Yaroslav Tsybovsky0
Yongping Yang0
Date of Patent
January 23, 2024
0Patent Application Number
175243800
Date Filed
November 11, 2021
0Patent Citations
Patent Primary Examiner
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