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US Patent 11879004 Modified binding polypeptides for optimized drug conjugation

Patent 11879004 was granted and assigned to Genzyme on January, 2024 by the United States Patent and Trademark Office.

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Patent Applicant

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Current Assignee

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Marie-Priscille Brun0

Qun Zhou0

Huawei Qiu0

Sunghae Park0

Francis Duffieux0

Date of Patent

January 23, 2024

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Patent Application Number

171870390

Date Filed

February 26, 2021

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Patent Citations

US Patent 8163881 Immunoglobulin molecules with improved characteristics

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US Patent 6998253 Altered polypeptides with increased half-life

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US Patent 7083784 Molecules with extended half-lives, compositions and uses thereof

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US Patent 7521541 Cysteine engineered antibodies and conjugates

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US Patent 7612181 Dual variable domain immunoglobulin and uses thereof

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US Patent 10744204 Conjugated compounds comprising cysteine-engineered antibodies

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Patent Primary Examiner

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Patent abstract

Engineered antibodies that are stable and can be conjugated to a ligand or drug at a ligand/drug to antibody ratio of above 3, making these conjugates suitable for treatment of a variety of indications, are provided. Methods of producing these engineered antibodies are also provided.

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