Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
E. Sally Ward Ober0
Date of Patent
April 24, 2012
Patent Application Number
11445475
Date Filed
May 31, 2006
Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides for IgG1 molecules with improved characteristics. In particular, substitution mutations are provided that, in combination, facilitate improved placental transfer, improved serum half-life and improved FcRn binding. Substitution mutations are also provided, that in combination, can be used to block FcRn function and thereby increase the clearance rates of other (endogenous or exogenous) IgGs, block placental transport of IgGs and have increased affinity/reduced pH dependence for FcRn binding.
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