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US Patent 11884739 Anti-CD20 glycoantibodies and uses thereof

Patent 11884739 was granted and assigned to Academia Sinica on January, 2024 by the United States Patent and Trademark Office.

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 US Patent 11884739 Anti-CD20 glycoantibodies and uses thereof

Article

Patent abstract

The present disclosure relates to a novel class of anti-CD20 monoclonal antibodies comprising a homogeneous population of anti-CD20 IgG molecules having the same N-glycan on each of Fc. The antibodies of the invention can be produced from anti-CD20 monoclonal antibodies by Fc glycoengineering. Importantly, the antibodies of the invention have improved therapeutic values with increased ADCC activity and increased Fc receptor binding affinity compared to the corresponding monoclonal antibodies that have not been glycoengineered.

Infobox
Is a
Patent
Patent
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Patent Applicant
Academia Sinica
Academia Sinica
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Current Assignee
Academia Sinica
Academia Sinica
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
118847390
Patent Inventor Names
Chi-Huey Wong0
Chung-Yi Wu0
Ming-Hung Tsai0
Date of Patent
January 30, 2024
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Patent Application Number
172116190
Date Filed
March 24, 2021
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Patent Primary Examiner
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Sharon X Wen
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