Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Richard Yu-Cheng Huang0
Aaron P. Yamniuk0
Stephen Michael Carl0
Derek A. Holmes0
Michael L. Gosselin0
Achal Pashine0
Priyanka Apurva Madia0
Guodong Chen0
Date of Patent
March 5, 2024
0Patent Application Number
174723020
Date Filed
September 10, 2021
0Patent Citations
Patent Primary Examiner
Patent abstract
Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more FcγRs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.
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