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US Patent 11946063 Long germline DH genes and long HCDR3 antibodies

Patent 11946063 was granted and assigned to Trianni, Inc. on April, 2024 by the United States Patent and Trademark Office.

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Patent abstract

The invention relates to a long DH (LDH) cassette comprising a recombinant DH construct comprising at least two DH gene segments encoding at least 10 amino acids of the HCDR3 amino acid sequence, wherein at least one of the DH gene segments is a heterologous DH gene segment; an immunoglobulin heavy chain locus and a transgenic non-human animal comprising the same; and their use in producing an immunoglobulin library with long HCDR3 regions.

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