Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Susan Klapholz0
Aya Jakobovits0
Larry Green0
Michael J Mendez0
Raju Kucherlapati0
Date of Patent
June 20, 2006
0Patent Application Number
100789580
Date Filed
February 19, 2002
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (VH and Vκ) gene regions. Advantageously, the inclusion of plural variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B-cell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high affinity antibodies.
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