Patent 11976044 was granted and assigned to Ocuphire Pharma, Inc. on May, 2024 by the United States Patent and Trademark Office.
This invention provides methods for synthesizing phentolamine mesylate from phentolamine and methanesulfonic acid in the presence of acetone and water. The methods of the present invention provide highly pure phentolamine mesylate. The invention also provides highly pure phentolamine mesylate.