Patent 11988668 was granted and assigned to Regeneron Pharmaceuticals on May, 2024 by the United States Patent and Trademark Office.
Methods for producing high concentration protein formulations having high stability are provided. Assays for selecting proteins and formulation conditions that have high self-repulsive attributes are used as an early step in the manufacturing process. Specifically, a protein concentration-dependent self-interaction nanoparticle spectroscopy method is employed as a protein colloidal interaction assay.