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US Patent 12004495 Genetically modified non-human animals with humanized immunoglobulin locus

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 US Patent 12004495 Genetically modified non-human animals with humanized immunoglobulin locus

Article

Patent abstract

The present disclosure relates to genetically modified animals and cells with humanized heavy chain immunoglobulin locus and/or humanized light chain immunoglobulin locus.

Infobox
Is a
Patent
Patent
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
120044950
Patent Inventor Names
Hui Lu0
Huizhen Zhao0
Jiawei Yao0
Lili Liu0
Shuwen Huang0
Yabo Zhang0
Yuelei Shen0
Date of Patent
June 11, 2024
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Patent Application Number
170105870
Date Filed
September 2, 2020
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Patent Citations
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US Patent 7105348 Methods of modifying eukaryotic cells
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US Patent 7129084 Production of humanized antibodies in transgenic animals
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US Patent 7262028 Recombinant production of mixtures of antibodies
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US Patent 7541513 Mouse λ light chain locus
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US Patent 7816578 Transgenic transchromosomal rodents for making human antibodies
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US Patent 8367888 Mouse λ light chain locus
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US Patent 8502018 Methods of modifying eukaryotic cells
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US Patent 8759105 Method for genetically modifying mouse embryonic stem cell by homologous recombination
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US Patent 8791323 Hybrid antibodies comprising human variable regions and mouse constant regions produced in a genetically modified mouse
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US Patent 8846402 Method for genetically modifying isolated non-human mammalian cell by homologous recombination
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US Patent 8877688 Rationally designed, synthetic antibody libraries and uses therefor
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US Patent 8907157 Methods for producing transgenic rodents having recombinant immunoglobulin loci
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US Patent 9253965 Animal models and therapeutic molecules
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US Patent 9353394 Methods of producing hybrid antibodies
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US Patent 9371553 Genetically modified mice that produce hybrid antibodies
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US Patent 9376699 Methods of producing hybrid antibodies
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US Patent 9382567 Methods of producing hybrid antibodies
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US Patent 9388446 Methods of producing hybrid antibodies
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US Patent 9434782 Animal models and therapeutic molecules
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US Patent 9439405 Mouse λ light chain locus
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US Patent 9445581 Animal models and therapeutic molecules
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US Patent 9447177 Transgenic mouse homozygous for chimeric IgH locus
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US Patent 9504236 Animal models and therapeutic molecules
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US Patent 9505827 Animal models and therapeutic molecules
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US Patent 9528136 Methods of modifying eukaryotic cells
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US Patent 9677129 Method for detecting the replacement of an endogenous allele with a modified allele by homologous recombination in a mouse ES cell
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US Patent 9708635 Methods of making a nucleic acid encoding a human variable region
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US Patent 9783593 Antibodies, variable domains and chains tailored for human use
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US Patent 9788534 Animal models and therapeutic molecules
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US Patent 9896516 Animal models and therapeutic molecules
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US Patent 9924705 Animal models and therapeutic molecules
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US Patent 9938357 Animal models and therapeutic molecules
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US Patent 9938358 Animal models and therapeutic molecules
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US Patent 9963501 B cell lineage based immunogen design with humanized animals
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US Patent 10064398 Animal models and therapeutic molecules
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US Patent 10149462 Animal models and therapeutic molecules
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US Patent 10165763 Animal models and therapeutic molecules
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US Patent 10194645 Mouse λ light chain locus
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US Patent 10226033 Animal models and therapeutic molecules
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US Patent 10227625 Methods of modifying eukaryotic cells
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US Patent 10251377 Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
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US Patent 10344299 Compositions and methods for modifying cells
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US Patent 10378037 Methods of making a nucleic acid encoding a human variable region
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US Patent 10378038 Mice that produce hybrid antibodies
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US Patent 10378039 Mouse embryonic stem cells comprising a hybrid heavy chain immunoglobulin locus
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US Patent 10378040 Mice that produce hybrid antibodies
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US Patent 10526630 Genetically modified mice that produce hybrid antibodies
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Patent Primary Examiner
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Allison M Fox
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